{"id":9988,"date":"2023-10-31T09:59:13","date_gmt":"2023-10-31T08:59:13","guid":{"rendered":"https:\/\/diario.m-achermann.com\/who-i-was-and-who-i-am\/chronic-myeloid-leukemia-cml-what-is-it\/"},"modified":"2026-04-01T17:03:31","modified_gmt":"2026-04-01T15:03:31","slug":"chronic-myeloid-leukemia-cml-what-is-it","status":"publish","type":"page","link":"https:\/\/diario.m-achermann.com\/en\/who-i-was-and-who-i-am\/chronic-myeloid-leukemia-cml-what-is-it\/","title":{"rendered":"Chronic Myeloid Leukemia (CML), What Is It?"},"content":{"rendered":"\n

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It looks like a beautiful abstract painting, but instead: A small megakaryocyte<\/a> with hypolobated nucleus in a bone marrow aspirate from a patient with chronic myeloid leukemia<\/figcaption><\/figure>\n<\/div>\n

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The Disease<\/strong><\/p>\n\n

Chronic myeloid leukemia<\/strong> (CML<\/strong>) is a pathological clinical condition caused by the uncontrolled monoclonal<\/a> proliferation of a single multipotent cell that has undergone neoplastic transformation.The disease can involve the myeloid, monocytic, erythroid, megakaryocytic lineages and sometimes also the lymphoid compartment.The years 2005-2010 saw a radical change in the therapy and prognosis of chronic myeloid leukemia, achieved through the use of knowledge about the molecular pathogenesis of the disease; the improvement has been compared to the discovery of antibiotics for the treatment of diseases caused by bacteria.<\/strong>There are many possible treatments for chronic myeloid leukemia, but the standard for new diagnoses is therapy with Imatinib<\/a>.Compared to most anti-cancer drugs, imatinib has relatively few side effects and can be taken orally at home. With this drug, more than 90% of patients are able to keep the disease under control for at least five years, so that the chronic condition becomes manageable. Source: https:\/\/it.wikipedia.org\/wiki\/Leucemia_mieloide_cronica<\/a><\/em><\/p>\n\n

Epidemiology<\/strong><\/p>\n\n

The incidence in industrialized countries is 2 cases per 100,000 people\/year; regarding gender, males are more affected (M:F ratio = 2:1).It affects all ages, with 20-25% of cases being over 60 years old.The median age at diagnosis is 45-50 years; in Italy there are approximately 800-1,000 new cases every year and the total number of patients is approximately 10,000, constantly increasing.Source: https:\/\/it.wikipedia.org\/wiki\/Leucemia_mieloide_cronica<\/a><\/em><\/p>\n\n

Chronic myeloid leukemia in Switzerland 2000-2007, from<\/strong> Cancer in Switzerland, 2015 report<\/a><\/strong> <\/p>\n\n

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